SARS–CoV–2 Spike Impairs DNA Damage Repair and Inhibits V(D)J Recombination In Vitro

 

Viruses | 13 October 2021

 

Abstract 

Severe acute respiratory syndrome coronavirus 2 (SARS–CoV–2) has led to the coronavirus disease 2019 (COVID–19) pandemic, severely affecting public health and the global economy. Adaptive immunity plays a crucial role in fighting against SARS–CoV–2 infection and directly influences the clinical outcomes of patients. Clinical studies have indicated that patients with severe COVID–19 exhibit delayed and weak adaptive immune responses; however, the mechanism by which SARS–CoV–2 impedes adaptive immunity remains unclear. Here, by using an in vitro cell line, we report that the SARS–CoV–2 spike protein significantly inhibits DNA damage repair, which is required for effective V(D)J recombination in adaptive immunity. Mechanistically, we found that the spike protein localizes in the nucleus and inhibits DNA damage repair by impeding key DNA repair protein BRCA1 and 53BP1 recruitment to the damage site. Our findings reveal a potential molecular mechanism by which the spike protein might impede adaptive immunity and underscore the potential side effects of full-length spike-based vaccines.

 

viruses-13-02056-v2

 

 

Source: https://www.mdpi.com/1999-4915/13/10/2056/htm

 

 

Here is a quote from the article published by Mike Adams in Natural News on how the spike protein in the vaccines can inhibit the healthy DNA repair mechanisms:

 

The DNA repair mechanism, known as NHEJ (Non-Homologous End Joining) is a kind of intracellular “emergency response” system that repairs double-stranded DNA breaks. Without the NHEJ mechanism, all advanced multi-cellular life would cease to exist. No human being, animal or plant can survive with the integrity of its genetic code being protected and constantly repaired through multiple mechanisms.

DNA damage can be caused by exposure to radiation, chemicals found in foods and personal care products, or even exposure to mammography equipment. Excessive sunlight exposure can also cause DNA breaks, and minor DNA mutations occur spontaneously in all living organisms.

In a normal, healthy person, the NHEJ mechanism repairs the DNA and prevents a bad mutation from occurring. But in the presence of the vaccine spike protein, NHEJ effectiveness is suppressed by as much as 90%, meaning it is unable to do its job due to the suppressed ability to recruit proteins for repair.

As a result, the following “errors” are introduced into chromosomes inside the nuclei of human cells:

    • Mutations or “errors” in the genetic sequence.
    • DELETIONS of entire segments of genetic code.
    • INSERTIONS of incorrect segments.
    • Mixing and matching / permutations of genetic code.

These errors, when expressed through cell division and replication, result in:

    • An explosion in cancer and cancer tumors throughout the body
    • Loss of production of immune system B and T cells (i.e. induced immunodeficiency)
    • Autoimmune disorders
    • Accelerated aging and reduced telomere length
    • Loss of functioning of complex organ systems such as circulatory, neurological, endocrine, muskuloskeletal, etc.
    • Cellular damage resembling radiation poisoning as cells destroy themselves from within

Many of these effects are, of course, fatal. Others will burden vaccine victims with horrendous debilitating injuries and organ malfunctions that will require a lifetime of medical intervention.

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