Potential Cardiotoxic Efects of Remdesivir on Cardiovascular System: A Literature Review


Cardiovascular Toxicology | Accepted 7 October 2021



Some patients with COVID-19 infection on remdesivir may develop sinus bradycardia, hypotension, T-wave abnormalities, AF, and a prolonged QT interval. Also, few cases of cardiac arrest and complete heat block following remdesivir infusion have been reported. It seems remdesivir have some cardiotoxic and proarrhythmic effects that are especially more pronounced in patients with previous cardiovascular diseases. Continuous cardiac rhythm monitoring is recommended in patients undergoing remdesivir treatment. It is especially advisable in individuals with any known cardiac diseases or electrolyte disturbances. Furthermore, we should be more cautious about additive cardiovascular adverse effects when other drug classes are used in addition to remdesivir treatment. It is due to the fact that their combination may increase the risk of potential fatal ventricular arrhythmias or cardiac arrest. The current safety profile of remdesivir is still not completely known. Further prospective clinical trials can assist us to know more about its safety profile and potential adverse cardiovascular effects.






Source: https://link.springer.com/article/10.1007/s12012-021-09703-9